The hierarchical structural architecture of inflammasomes, supramolecular inflammatory machines
نویسندگان
چکیده
منابع مشابه
The hierarchical structural architecture of inflammasomes, supramolecular inflammatory machines.
Inflammasomes are caspase-1 activating, molecular inflammatory machines that proteolytically mature pro-inflammatory cytokines and induce pyroptotic cell death during innate immune responses. Recent structural studies of proteins that constitute inflammasomes have yielded fresh insights into their assembly mechanisms. In particular, these include a crystal structure of the CARD-containing NOD-l...
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ژورنال
عنوان ژورنال: Current Opinion in Structural Biology
سال: 2015
ISSN: 0959-440X
DOI: 10.1016/j.sbi.2015.03.014